Database

SynAffix

Solution provided
Technology
Supplier identity
General description

SynAffix’ is a life sciences company with a unique chemoenzymatic technology for site-specific conjugation of recombinant (glyco)proteins. SynAffix' approach involves the enzymatic introduction of a specific tag, followed by fast and irreversible chemical functionalization through metal-free click. A particular focus lies in the development of next generation antibody-drug conjugates (ADCs), with full control of stability, site-specificity and drug-antibody ratio.

Type of Supplier
Biotechnology Company - Therapeutics
Sector of activity
  • Cancer / Oncology
  • Drug Discovery / Research & Development
  • Immunology
  • Nuclear medicine
  • Protein Therapeutics
Region
Province of Gelderland, NL
Regional access broker
  • Karien Croezen, Oost N.V. & Health Valley
Activity description
The 3 top equipments available

All requisite equipment for organic chemistry (NMR, HPLC, LC-MS, MALDI, IR, UV, fluorescence).

All requisite equipment for molecular biology (FPLC, centrifuges, incubators, blotting equipment).

Know-how, expertise available

SynAffix can provide molecular probes and advice for application of copper-free click chemistry for bioconjugation or for the preparation of materials (e.g. immobilization on glass or polystyrene).

Secondly, SynAffix can provide technology and services for site-specific conjugation to proteins and oligonucleotides. Several tools are available for proteins ranging from small proteins (<10 kD) up to monoclonal antibodies (150 kD).

Possibilities of partnership

SynAffix can provide extensive knowledge and tools to any project that requires the controllend functionalization of biomolecular structures (peptides, proteins, nucleic acids, glycans). Examples thereof involve fluorescent or radionuclide labeling, biotinylation, immobilization (surfaces, magnetic beads, nanoparticles, etc), but also dimerization of biomolecules or hybrid structures (nucleopeptides, glycoproteins, peptidoglycans).

SynAffix expertise extends from fundamental organic chemistry (methodology development and total synthesis) to biochemistry/molecular biology (protein expression, mutagenesis, fusion proteins).

Training and Staff possibilities
Yes
Contact information
Name
van Delft
Surname
Floris
Function
CSO
Phone number
+31(0)24 - 365 2373
Address
Heyendaalseweg 135
6525 AJ  Nijmegen
Netherlands